#march2020mccqe1
A 13-year-old boy is diagnosed with a hyperactive immune system. Normally an antigen will activate the immune system to trigger a proinflammatory response. Following the proinflammatory response, anti-inflammatory signals then dampen the immune response to prevent it from causing damage. This patient has trouble dampening the immune response after it is no longer needed. Decreased activity in which of the following anti-inflammatory cytokines is most likely the basis for this boy’s condition?
(A) Interferon-γ
(B) Interleukin-1
(C) Transforming growth factor-β
(D) Tumor necrosis factor-α
(E) Tumor necrosis factor-β
A 13-year-old boy is diagnosed with a hyperactive immune system. Normally an antigen will activate the immune system to trigger a proinflammatory response. Following the proinflammatory response, anti-inflammatory signals then dampen the immune response to prevent it from causing damage. This patient has trouble dampening the immune response after it is no longer needed. Decreased activity in which of the following anti-inflammatory cytokines is most likely the basis for this boy’s condition?
(A) Interferon-γ
(B) Interleukin-1
(C) Transforming growth factor-β
(D) Tumor necrosis factor-α
(E) Tumor necrosis factor-β
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