#june2020mccqe1
A 24-year-old woman suffers from epistaxis, gingival bleeding, and menorrhagia. Her mother and grandmother have similar symptoms, and her brother has incisional bleeding after surgery and dental extractions. They all have similar laboratory findings, including a prolonged bleeding time, reduced levels of factor VIII antigen, normal platelet aggregation, and reduced ristocetin cofactor activity. This family has disorder characterized by a deficient or defective protein. In normal patients, which of the following binds to the affected protein at the platelet membrane?
(A) Adenosine diphosphate (ADP)
(B) Calcium
(C) Glycoprotein GPIb
(D) Platelet factor 3 (PF3)
(E) Prostacyclin
(F) Serotonin
(G) Thromboplastin
(H) Thromboxane A2
A 24-year-old woman suffers from epistaxis, gingival bleeding, and menorrhagia. Her mother and grandmother have similar symptoms, and her brother has incisional bleeding after surgery and dental extractions. They all have similar laboratory findings, including a prolonged bleeding time, reduced levels of factor VIII antigen, normal platelet aggregation, and reduced ristocetin cofactor activity. This family has disorder characterized by a deficient or defective protein. In normal patients, which of the following binds to the affected protein at the platelet membrane?
(A) Adenosine diphosphate (ADP)
(B) Calcium
(C) Glycoprotein GPIb
(D) Platelet factor 3 (PF3)
(E) Prostacyclin
(F) Serotonin
(G) Thromboplastin
(H) Thromboxane A2
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