A 36-year-old woman with end stage renal disease secondary to polycystic kidney disease undergoes renal transplantation. On the tenth postoperative day she complains of general malaise, appears mildly ill, and has decreased urine output. What is the most likely pathologic mechanism underlying this patient’s current illness?
A. Donor T-lymphocytes reacting against recipient major histocompatibility complexes (MHCs)
B. Immune complex deposition within renal artery walls
C. Immune complex deposition within renal glomerular subendothelium
D. Preformed anti-donor antibodies reacting against donor antigens
E. Recipient cytotoxic T-lymphocytes reacting against donor major histocompatibility complexes (MHCs)
A. Donor T-lymphocytes reacting against recipient major histocompatibility complexes (MHCs)
B. Immune complex deposition within renal artery walls
C. Immune complex deposition within renal glomerular subendothelium
D. Preformed anti-donor antibodies reacting against donor antigens
E. Recipient cytotoxic T-lymphocytes reacting against donor major histocompatibility complexes (MHCs)