A 40-year-old man presents to his physician with numbness and tingling on the dorsal surface of his right hand and forearm and raised “varicose veins”

Subject
Medicine
System
Allergy & Immunology

Kathryn

Member
Jul 29, 2020
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Singapore
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A 40-year-old man presents to his physician with numbness and tingling on the dorsal surface of his right hand and forearm and raised “varicose veins” that are firm to the touch along the same distribution. He also complains of weight loss. His serum creatinine level is 2.0 mg/dL. He has no previous medical history of significance. An immune complex disease is suspected, and assays for autoantibodies in neutrophils are conducted. What diseases are associated with the identification of anti-myeloperoxidase and anti-proteinase-3 antibodies, respectively?
(A) Kawasaki’s disease, Buerger’s disease
(B) Microscopic polyangiitis, Wegener’s granulomatosis
(C) Polyarteritis nodosa, Buerger’s disease
(D) Takayasu’s arteritis, Wegener’s granulomatosis
(E) Temporal arteritis, Wegener’s granulomatosis