#june2020usmle2ck
A 42 year-old woman presents to the clinic with progressive fatigue and weakness for 6 months. She also complains of tingling and numbness of her arms and legs. Physical examination reveals decreased both superficial and deep sensations in her arms and legs. Blood count reveals decreased numbers of erythrocytes, leucocytes and platelets along with increased mean red blood cell volume. Peripheral blood smear shows enlarged erythrocytes and hypersegmented neutrophils.
Which one of these biochemical reactions is involved in this case?
A- Conversion of propionyl –CoA to methylmalonyl –CoA
B- Conversion of methylmalonyl-CoA to succinyl-CoA
C- Conversion of succinyl-CoA to fumarate
D- Conversion of malonyl-CoA to palmitate
A 42 year-old woman presents to the clinic with progressive fatigue and weakness for 6 months. She also complains of tingling and numbness of her arms and legs. Physical examination reveals decreased both superficial and deep sensations in her arms and legs. Blood count reveals decreased numbers of erythrocytes, leucocytes and platelets along with increased mean red blood cell volume. Peripheral blood smear shows enlarged erythrocytes and hypersegmented neutrophils.
Which one of these biochemical reactions is involved in this case?
A- Conversion of propionyl –CoA to methylmalonyl –CoA
B- Conversion of methylmalonyl-CoA to succinyl-CoA
C- Conversion of succinyl-CoA to fumarate
D- Conversion of malonyl-CoA to palmitate
