A 45-year-old woman had a lumpectomy, postoperative radiotherapy, adjuvant chemotherapy and tamoxifen therapy at the age of 42 years

Subject
Obstetrics and Gynaecology
System
Female Reproductive System & Breasts

Kathryn

Member
Jul 29, 2020
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Singapore
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A 45-year-old woman had a lumpectomy, postoperative radiotherapy, adjuvant chemotherapy and tamoxifen therapy at the age of 42 years for an oestrogen receptor-positive breast malignancy. She was prescribed tamoxifen in a dose of 10mg per day and was to take it for the next five years. From the time she completed her chemotherapy three years ago, she had no menstrual periods until one week ago when she had an episode of light vaginal bleeding lasting for seven days. She is still taking the tamoxifen. Which one of the following is the most likely cause for the recent bleeding?
(A) Induction of follicular development by the tamoxifen
(B) Endometrial polyp formation due to the tamoxifen
(C) An endometrial cancer produced by the tamoxifen
(D) Endometrial atrophy due to the tamoxifen
(E) An endometrial metastasis from the breast cancer