A 45-year-old woman with systemic lupus erythematosus (SLE) comes to the physician for a routine checkup.

Subject
Medicine
System
Allergy & Immunology, Public Health & Preventive Medicine

Kathryn

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Jul 29, 2020
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A 45-year-old woman with systemic lupus erythematosus (SLE) comes to the physician for a routine checkup. Her condition has been stable for several years, and she currently is not taking any medication. Blood chemistry studies and hematologic parameters are remarkable for a blood urea nitrogen (BUN) of 23 mg/dL, a creatinine of 1.6 mg/dL, and a mild normocytic anemia. The erythrocyte sedimentation rate is 18 mm/min. Urinalysis shows microhematuria and mild proteinuria. Which of the following is the most appropriate next step in management?
(A) Repeat urinalysis at next routine examination
(B) Sequential serum complement and ANA studies
(C) Treatment with corticosteroids
(D) Treatment with cyclophosphamide
(E) Renal biopsy
 
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