#february2020mccqe1
A 5-year-old boy is brought to his pediatrician because he has been complaining of fatigue and headache for several weeks. On examination he has enlarged lymph nodes and is sent for a bone marrow biopsy. The biopsy shows large lymphoblasts with prominent nucleoli and light blue cytoplasm, and the patient is diagnosed with acute lymphoid leukemia. He is treated with high-dose glucocorticoids, intravenous and intrathecal methotrexate, cyclophosphamide, doxorubicin, and vincristine. He achieves a full remission. Which of the following accurately matches the causative drug with the possible adverse effect that he may experience now or in the future?
(A) Cyclophosphamide: hearing loss
(B) Glucocorticoids: cataracts
(C) Glucocorticoids: peripheral neuropathy
(D) Methotrexate: cognitive deficit
(E) Methotrexate: pulmonary fibrosis
A 5-year-old boy is brought to his pediatrician because he has been complaining of fatigue and headache for several weeks. On examination he has enlarged lymph nodes and is sent for a bone marrow biopsy. The biopsy shows large lymphoblasts with prominent nucleoli and light blue cytoplasm, and the patient is diagnosed with acute lymphoid leukemia. He is treated with high-dose glucocorticoids, intravenous and intrathecal methotrexate, cyclophosphamide, doxorubicin, and vincristine. He achieves a full remission. Which of the following accurately matches the causative drug with the possible adverse effect that he may experience now or in the future?
(A) Cyclophosphamide: hearing loss
(B) Glucocorticoids: cataracts
(C) Glucocorticoids: peripheral neuropathy
(D) Methotrexate: cognitive deficit
(E) Methotrexate: pulmonary fibrosis
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