A 55 year old woman presents to her physician with complaints of bilateral joint pain in her wrists, hands, and knees, muscle aches, fatigue, and malaise for the past two months. Her past medical history includes uncontrolled hypertension, for which she was prescribed hydralazine 3 months ago. Laboratory testing reveals a positive ANA, however anti-DS DNA antibodies are negative. Which of the following antibodies would be most specific to her disease?
A. Antihistone
B. Anticentromere
C. Antiscleroderma-70
D. Anti-Sm
E. Anti-uroporphyrin isomerase ribonucleoprotein
A. Antihistone
B. Anticentromere
C. Antiscleroderma-70
D. Anti-Sm
E. Anti-uroporphyrin isomerase ribonucleoprotein