A 66-year-old woman has an autosomal recessive disease with multiple sequelae, including diabetes mellitus and arthritis. Physical examination reveals

Subject
Medicine
System
Gastrointestinal & Nutrition

Kathryn

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Jul 29, 2020
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A 66-year-old woman has an autosomal recessive disease with multiple sequelae, including diabetes mellitus and arthritis. Physical examination reveals hepatomegaly and skin hyperpigmentation. A biopsy of her liver is shown in the image. What is the most likely explanation for her health problems?
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(A) Chronic ingestion of alcohol
(B) Genetic deficiency in the synthesis of β-globin chains
(C) Inappropriately high iron absorption
(D) Mutation in RBC membrane protein
 
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