After a 63-year-old man with a progressive, chronic movement disorder dies, the family requests an autopsy. On gross inspection of the patient’s brain

Subject
Medicine
System
Nervous System

Kathryn

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Jul 29, 2020
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After a 63-year-old man with a progressive, chronic movement disorder dies, the family requests an autopsy. On gross inspection of the patient’s brain, the pathologist notes the presence of a deep brain stimulator electrode. The pathologist then obtains a tissue specimen of the basal ganglia for histologic analysis (see image) that stains positive for α-synuclein. From which disease did the decedent most likely suffer?
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(A) Guillain-Barré syndrome
(B) Huntington’s disease
(C) Parkinson’s disease
(D) Pick’s disease
(E) Werdnig-Hoffmann disease
 
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