An 8-year-old boy presents to your clinic with a history of nonproductive cough and recurrent opportunistic infections. His mother claims that the symptoms first arose about 2 years ago and previous physicians suspected an immune deficiency disorder. A chest X-ray reveals patchy infiltrates and diffuse clouding. Bronchiolar lavage identifies numerous neutrophils arranged in isolated conglomerates. Nitroblue tetrazolium dye reduction test is negative. Which enzyme is most likely deficient in this child?
A. Alpha-ketoglutarate dehydrogenase
B. Dihydrofolate Reductase
C. Glutathione Reductase
D. NADPH Oxidase
E. Topoisomerase
A. Alpha-ketoglutarate dehydrogenase
B. Dihydrofolate Reductase
C. Glutathione Reductase
D. NADPH Oxidase
E. Topoisomerase