Workers in the aniline dye industry are more susceptible to bladder cancer than general population. Meanwhile, studies show that animals, when exposed

[Joyce]

#january2020usmle2k

Workers in the aniline dye industry are more susceptible to bladder cancer than general population. Meanwhile, studies show that animals, when exposed to beta-naphthylamine develop liver cancer but not bladder cancer.

What is the most likely explanation of this finding?

A-Metabolism of beta-naphthylamine by human cytochrome 450 system in the liver
B-Detoxification of beta-naphthylamine by glucuronic acid conjugation.
C-Human urinary glucuronidase splits beta-naphthylamine into glucuronic acid and a toxic metabolite.
D-Beta-naphthylamine is directly carcinogenic to human bladder

 

[Tiffany Wong]

C-Human urinary glucuronidase splits beta-naphthylamine into glucuronic acid and a toxic metabolite.